When we think of skincare, the immediate picture that comes to our mind is typically a cream, serum, or lotion that we apply directly on our face. This classic approach, working from the outside in, has been the foundation of both medical and cosmetic dermatology for a long time. But there is another, equally important point of view to consider: from the inside out. This dual pathway is the key to holistic skin health.

There are three main layers that make up our skin

Epidermis: the outermost layer, consisting of cells that are always regenerating. The epidermis has no blood supply.

Dermis: the middle layer, rich in blood vessels, collagen, elastin, glands, and nerve endings.

Hypodermis: the lowest layer, which contains fat cells and larger blood vessels.

What this means in practice is that topical applications – whether serums, moisturizers, or retinol – only work their way from the outside in. Because the epidermis has no blood supply, active ingredients applied to the skin must penetrate its layers to have any effect. This understanding is well recognized in the field of dermatology and serves as the foundation for the layered formulation of many products. But here is where the holistic view gets more interesting.

The Inside-Out Route

Supplements like collagen peptides or pycnogenol and even MSM undergo a different absorption process compared to topical products. They are absorbed through the gut and enter the bloodstream to dermally and hypodermically accessible layers through the vascular system.

This route – inside to outside – offers a way to nourish the skin at a depth that topical treatments often can’t reach. The dermis, where collagen and elastin are present, as well as the fibroblasts, has metabolic activity where rejuvenation occurs, and is best accessed through the skin’s internal circulation.

Importance of Holistic Approach in Today's World

Exposomal stress is becoming a growing global issue, from UV exposure and pollution to insufficient sleep and unhealthy eating habits. Focusing on the skin through a singular approach often leads to minimized benefit.

A more comprehensive strategy includes

Topical products to maintain the barrier, provide UV and blue light defense, and manage visible skin concerns such as acne or pigmentation.

Oral nutraceuticals to defend against oxidative stress, improve collagen synthesis, and help feed the skin's deeper structural layers.

This is especially important in conditions such as accelerated aging, inflammatory skin disorders, or barrier dysfunction, wherein the dermis requires as much assistance as the epidermis.

The Future of Skin Health

Today, there is a greater scope for multifaceted approaches. For example, a strong antioxidant serum works exceptionally well in synergy with a clinically proven oral collagen peptide supplement that enhances dermal collagen density. Over time, the skin becomes more resilient and healthy.

What’s the main takeaway for us? Maintaining skin health goes beyond what we put on the surface. It also depends on how the body is nourished and supported from within. This is where the inside out strategy completes the holistic approach, ensuring long term skin health.

You can explore CHOSEN Communities for more science backed, holistic skincare insights.