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Sesderma Retiage is one of the more potent vitamin A night creams out there. This product has a faithful follower base, but may be a tad strong for beginners. As with all topical retinoids, Sesderma Retiage must be used on a clean, dry skin. Aim for a gentle application, as rubbing may cause irritation and redness. This product needs to be gently introduced, starting with a short contact time of 20 to 30 minutes, and then gradually increasing the contact time.